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KMID : 0356820020180020163
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Korean Journal of Head & Neck Oncology
2002 Volume.18 No. 2 p.163 ~ p.167
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Concomitant Chemoradiotherapy as Primary Therapy for Advanced Head and Neck Cancer)
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이주연
이동욱/최영석/진홍률/이현석/연제엽/신시옥
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Abstract
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Background: To achieve the efficacy and toxic effects of concomitant FP chemoradiotherapy regimen by means of response and survival in patients with advanced head and neck cancer.
Patient and Method: Thirty-three previously untreated patients with newly diagnosed advanced head and neck cancer were retrospectively reviewed.
Results: Thirty-one patients were evaluable for the tumor response. Total response rate was 93%(complete response 60%, partial response 33%). Disease free survival was 37 month and 3-year overall survival was 63%. Grade 3 or 4 stomatitis was observed in 83% and appeared as the dose limiting toxicity for this regimen.
Conclusion: Concomitant chemoradiotherapy with cisplastin and 5-fluorouracil is effective as primary therapy for advanced head and neck cancer. The majority of patients experienced severe stomatitis. Identification of less toxic regiment and improved disease control emerge as important future research goals.
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KEYWORD
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